| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Differential distribution and defence involvement of antimicrobial peptides in mussel
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| Autores: |
Mitta, Guillaume
Vandenbulcke, Franck
Noel, Thierry
Romestand, Bernard
Beauvillain, Jean Claude
Salzet, Michel
Roch, Philippe
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| Data: |
2000-08
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| Ano: |
2000
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| Palavras-chave: |
Innate immunity
Hemocyte
Mussel
Myticin
Mytilin
Defensin
Antimicrobial
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| Resumo: |
In previous papers, we characterised 3 types of 4-kDa, cysteine-rich, cationic antimicrobial peptides: MGDs (for Mytilus galloprovincialis defensins), mytilins and myticins, which are abundant in the mussel hemocytes. In the present work, me revealed a differential distribution of the cells expressing the different genes. In addition, using confocal and electron microscopy, we confirmed that defensins and mytilins were partially located in different sub-types of circulating hemocytes although the peptides can be located in the same cell, and even in the same granule. We also demonstrated that mytilins exert their microbicidal effect within the cells through the process of phagosome-mytilin granule fusion leading to the co-location of ingested bacteria and mytilins.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
http://archimer.ifremer.fr/doc/2000/publication-413.pdf
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| Editor: |
Company of Biologists
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| Relação: |
http://archimer.ifremer.fr/doc/00000/413/
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| Formato: |
application/pdf
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| Fonte: |
Journal of Cell Science (0021-9533) (Company of Biologists), 2000-08 , Vol. 113 , N. 15 , P. 2759-2769
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| Direitos: |
The Company of Biologists Limited 2000
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